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Rosbash investigates how biological clocks keep time and translate that timing into behavior. Using Drosophila, his research connects circadian genes, regulation of gene expression, and the neural circuits that coordinate daily rhythms. The laboratory studies transcriptional and post-transcriptional mechanisms, including feedback involving clock proteins, and examines the functions of individual circadian neurons. Biochemical and genetic approaches help identify regulatory mechanisms and clock components. This offers a specific connection between molecular biology and neuroscience: understanding both the cellular timing machinery and how a brain uses that machinery to organize rhythmic activity.
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