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How can living cells be reprogrammed to synthesize nonstandard oligomers and enable in vivo directed evolution? The Cornish Laboratory combines organic chemistry and DNA technology to expand cellular synthetic capabilities and harness the ribosome for unnatural oligomer synthesis. The laboratory engineers yeast to enable directed evolution of molecules and metabolic pathways directly in living cells for evolving new functions. Researchers apply these synthetic biology methods to create tools for bioimaging, molecular diagnostics, and therapeutic molecule generation. The group integrates chemical and genetic strategies to incorporate synthetic amino acid building blocks into biological polymers.
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