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Can engineered genetic systems be used to selectively suppress disease-vector mosquito populations while limiting ecological spread? The group develops conditional and female-lethal genetic approaches for mosquito control using CRISPR and precision genome editing. Researchers construct and test precision-guided sterile insect techniques and reciprocal chromosomal translocations to produce sterile or nonviable offspring in target mosquito species. The team deploys transcriptome engineering and synthetic viral circuitry to generate antiviral effectors and sensors that detect or disable arboviruses in mosquitoes. Experimental projects combine molecular genetics, transgenic lines, and population-level releases to evaluate confinement, inheritance bias, and operational suppression strategies.
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