Joshua Singer Research Group

University of Maryland, College Park

How do individual synapses in the rod bipolar cell pathway shape retina output under low-light conditions? The laboratory studies signaling in a retinal circuit called the rod bipolar cell pathway using recordings of electrical activity from neurons. They investigate synaptic transmission from rod bipolar cells to AII amacrine cells and analyze processing of rod bipolar outputs by AIIs and ganglion cells. Recordings are complemented by anatomical and computational analyses to understand circuit responses to visual stimuli. The group applies these approaches to develop broader principles of how neuron and synapse properties generate circuit behavior.