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A lipid can be much more than a structural part of a cell: it can carry a signal that changes cell behavior. Spiegel investigates sphingosine-1-phosphate, or S1P, and the enzymes that produce it. Her laboratory examines how this signaling system connects inflammation with cancer progression, metastasis, obesity, and metabolic and liver diseases. The work brings lipid metabolism and signal transduction together around mechanisms of disease. Researchers interested in biochemical pathways can explore how a small signaling molecule influences several distinct biological processes and why those connections matter for potential therapeutic targets.
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