Alexis Battle Research Group

Johns Hopkins University

How does genetic variation in noncoding DNA alter molecular phenotypes across human tissues? The group analyzes large-scale genomic sequencing data to study how genetic differences contribute to gene regulation and disease outcomes. The lab develops computational biology tools, statistical methods, and machine learning strategies to predict the effects of variation in noncoding DNA sequences. Researchers at the Battle Lab build integrative genomic networks and apply them to problems such as autism and rare Mendelian disease variant prediction. The lab also evaluates and predicts the impact of personal genomics and rare genetic variants to improve diagnosis of rare diseases.