Gregory Bowman Research Group

Johns Hopkins University

How do molecular motors rearrange the DNA packaging that controls access to genetic information? The group investigates chromatin remodelers, proteins that use energy from ATP to reposition nucleosomes. These small structures wrap DNA around histone proteins, making reorganization essential when cells need access to particular sequences. Research examines the mechanisms of the remodeling motors and how their activity is regulated. A central question is how additional protein domains communicate with the motor to select nucleosome substrates and produce different remodeling outcomes.