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How does post-transcriptional regulation of Notch pathway components control timing and patterning during vertebrate embryonic development? The research group uses genetics, molecular biology, mouse models, and embryology to study Notch signaling dynamics and post-transcriptional control of oscillatory genes such as Hes1, Hes7, and Lunatic fringe. Ongoing projects examine how Lunatic fringe and Deltalike-3 cooperate to regulate the segmentation clock that times somite formation and how small changes in expression or turnover perturb somitogenesis and skeletal patterning. The group also studies Notch pathway effects in cardiac development and disease using collaborations and genetic analyses.
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