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How do neuronal growth cones detect mechanical and chemical cues to direct axonal growth and regeneration? The Suter lab uses Aplysia and zebrafish models with quantitative live-cell imaging to measure growth cone dynamics. Projects include assays of reactive oxygen species in neuronal development, mechanosensing studies, zebrafish spinal cord injury drug screens, and in vivo axonal bulk cytoskeletal flow measurements. They combine cell biological, biophysical, molecular, and biochemical techniques to probe mechanisms underlying growth cone motility. The lab applies these experimental methods to develop treatments that enhance axonal regeneration after nervous system injury.
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neurosciencecellular and molecular biologyaxonal growthgrowth cones
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