Angela Mitchell Research Group

Texas A&M University

How do gram-negative bacteria strengthen their outer membrane permeability barrier during stress to resist antibiotics? The Mitchell Lab uses genetics and biochemistry to measure barrier changes and identify mechanisms that strengthen the outer membrane under stress. Researchers interrogate roles of specific membrane and periplasmic proteins in OM maintenance and adaptation using genetic suppressor analysis and biochemical assays. The group links OM barrier alterations to antibiotic resistance and pathogenesis through targeted functional experiments. Ongoing projects probe envelope stress responses and phospholipid transport mechanisms that determine membrane permeability.