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McLachlan Lab

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Why can immunity hold an infection in check without clearing it completely? James McLachlan studies antigen-specific CD4 helper T-cell responses during persistent bacterial infection, including a mouse model of chronic Salmonella. His group investigates antigen presentation and immunological memory, and uses peptide-MHC tetramers to follow rare T-cell populations. Related research examines how biological sex affects responses to infections and vaccines. These projects connect cellular immunology with the design of interventions that generate the right response in the right anatomical location.

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T-cell immunitySalmonellaImmunological memorySex differences

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