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Can human pluripotent stem cells be guided to form germ cells and ovarian tissues in vitro? The Clark Lab uses stem cell models and genome-scale assays to define cell and molecular origins of the ovarian reserve and primordial germ cells. The group applies single-cell analysis, genome engineering and machine learning to map lineage decisions and epigenetic reprogramming during germline specification. Researchers perform in vitro differentiation, transplantation and organoid-type reconstitution experiments to test mechanisms of gametogenesis and ovarian assembly. Comparative studies in primate and rodent systems validate developmental mechanisms relevant to fertility and ovarian aging.
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Stem Cell BiologyReproductive biologyGenetics
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