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Can injectable extracellular matrix hydrogels restore tissue structure and function after myocardial infarction using minimally invasive delivery? The lab develops infusible and catheter-deliverable decellularized extracellular matrix materials to target infarcted myocardium and preserve cardiac function. Researchers study immunomodulatory and pro-reparative gene expression responses using spatial and single-nucleus transcriptomics and animal myocardial infarction models. The group engineers enzyme-responsive nanoparticles and MMP-responsive polymeric materials for targeted delivery and controlled retention of therapeutics in injured heart tissue. The group creates vaginal and pelvic muscle extracellular matrix hydrogels to prevent pelvic floor dysfunction and promote skeletal muscle regeneration after birth injury.
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