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How does a defect in one ion channel leave the lungs vulnerable to disease? Michael Welsh investigates the structure and function of CFTR and how its disruption in cystic fibrosis changes airway defenses. His research uses porcine models of cystic fibrosis to connect molecular defects with the development of lung disease and to support the search for therapies. The work brings together ion-channel biology, innate immunity, and disease modeling, making it relevant to researchers interested in the mechanisms behind inherited pulmonary disorders.
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Cystic fibrosisCFTRAirway immunityDisease models
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