Jianhan Chen Research Group

University of Massachusetts

How can advanced simulation methods reveal mechanisms of intrinsically disordered proteins and biomolecular condensates at biologically relevant scales? The Chen Research Group develops theoretical and computational methods for molecular modeling and simulation applied to biophysical and biomedical problems. The group creates advanced conformational sampling algorithms, implicit solvent force fields, and GPU-accelerated simulation algorithms to study proteins and RNAs. Researchers apply multiscale simulations and physics-informed machine learning to generate dynamic conformational ensembles for IDPs, fibril formation, and ion channel gating. The lab collaborates with experimental groups to validate models and study disease-relevant systems like amyloid formation and membrane ion channel regulation.