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Hollingsworth investigates pancreatic disease through the biology of epithelial cells and mucin-associated molecules. His laboratory studies MUC1, including its expression and processing in normal cells compared with pancreatic cancer and other disease conditions. Research combines molecular biology, biochemistry, cell biology, and immunology, while developing antibodies and tumor-vaccine reagents that target tumor-associated mucin antigens. Other work supports discovery and validation of biomarkers for early pancreatic disease. The group connects detailed molecular mechanisms with diagnostic and immunotherapy research, making the transition from normal tissue biology to tumor behavior a central question.
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