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Sidi Chen Research Group
Yale UniversityMore labs at Yale University ↗An independent directory listingFind Research Labs maintains this page using public sources. The faculty member, lab, and university have not claimed or approved this listing. Listing a lab does not indicate endorsement, partnership, or a recruiting opportunity.
Request a correction or removal ↗ Which genes and cell-intrinsic factors control anti-tumor immunity in vivo? The Chen lab performs genome-scale in vivo CRISPR and CRISPRa screens in T cells and tumors to discover regulators of T cell infiltration, degranulation, and tumor immune evasion. The group develops AAV- and CRISPR-based engineering platforms (for example MAEGI and AAV-Cpf1 KIKO) to create and test immune-gene and CAR-T engineering strategies in mouse tumor models. Researchers combine high-throughput genetic screens with precision in vivo cancer models to map tumor-intrinsic suppressors and immune modulators. Technology development includes spatial and scalable perturbation methods to enable therapeutic target discovery.
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CRISPR screensimmunotherapyAAV engineeringCAR-Ttumor immunology
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