Papin Lab

University of Virginia (Main campus)

Can maps of cellular metabolism reveal how cells respond to disease and changes in their environment? The group reconstructs and analyzes large biochemical networks, combining high-throughput experimental data with mathematical and computational models. Researchers develop methods for incorporating measurements into network reconstructions and use experiments to test and improve model predictions. Applications include infectious disease, cancer, toxicology and metabolic engineering. The work connects the activity of many biochemical reactions with the behavior of whole cellular systems, seeking mechanisms relevant to human health.