Audrey Gasch Research Group

University of Wisconsin-Madison

How do fungal cells reprogram gene expression to survive environmental stresses and maintain cellular function? The lab investigates eukaryotic stress responses using genomics and systems-biology approaches to map expression changes. Researchers combine functional genomics, computational biology, genetics, and biochemistry to identify regulatory mechanisms that confer stress resistance. Projects measure genetic variation in environmental responses and study evolution of stress defense systems across fungal genomes. Experimental and computational methods are integrated to connect gene-expression programs to physiological outcomes under diverse stress conditions.