Valerie Horsley Research Group

Yale University

How do adult epithelial stem cells and non-epithelial neighbors coordinate to maintain tissue homeostasis, repair wounds, and influence fibrosis or tumorigenesis? The Horsley lab uses mouse genetics, cell culture, genomics, and microscopy to dissect cell-intrinsic and cell-extrinsic regulators of epithelial regeneration. Researchers study stem cell contributions to wound healing and scarring, the role of adipocytes and myeloid metabolism in skin repair, and molecular biomarkers of keloids and fibrosis. The group leverages clinical resources and collaborates across stem cell and engineering groups to address clinically relevant questions in epithelial biology and dermatology.