Leifu Chang Research Group

Purdue University West Lafayette

How do the structures of large protein and protein–nucleic acid assemblies determine their regulation and function at molecular resolution? The Chang group focuses on cryo-electron microscopy and biochemical reconstitution to solve structures of large complexes. Researchers apply X-ray crystallography, NMR, electron tomography, and advanced spectroscopy alongside computational approaches to examine nucleic acid and protein structures. Current projects document CRISPR-Cas systems and cell-cycle regulatory assemblies using structural methods to reveal mechanisms of action.