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A cancer biomarker is useful only if researchers understand what they are measuring. Rebecca Whelan studies the ovarian cancer marker CA125, including its structure and the sites recognized by antibodies. Her lab combines proteomics, microscale separations, bioinformatics, and affinity-reagent development to characterize biomarkers and improve recognition strategies. Research also develops aptamers against proteins and whole-cell targets, with potential uses in targeted delivery and simple detection devices. This connects analytical chemistry with the molecular details needed for better cancer measurement.
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Cancer biomarkersCA125AptamersProteomics
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