Arjun Raj Research Group

University of Pennsylvania

How do genetically identical cells adopt different molecular fates within tissues and tumors? The Raj lab studies the biology of single cells using measurements of individual RNA molecules via fluorescence microscopy and high throughput sequencing. The group develops and utilizes experimental tools including fluorescence microscopy and sequencing to make quantitative measurements of cellular behavior. Researchers apply computational image analysis and machine learning to enable accurate spot detection and accelerate analysis of microscopy and sequencing data. The lab investigates how rare cells and multicellular organization drive outcomes like drug resistance and self-organization in cancer.