David Green Research Group

Stony Brook University

Proteins recognize particular partners, and understanding that specificity can help researchers design new interactions. Green uses computational methods to investigate protein binding and interaction networks. His research includes biomolecular simulations, algorithms for designing binding interfaces, and tools for examining interactions between proteins and carbohydrates. A particular application concerns the glycobiology of HIV-1 infection. By combining applied mathematics with models from biophysical chemistry, the work connects molecular recognition with biological and medical questions about how proteins interact and how those interactions might be redesigned.