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Bierbach designs drug candidates that combine organic molecules with metal-based chemistry. His laboratory investigates platinum-acridine hybrid anticancer agents, linking chemical structure with biological activity and mechanisms of action. Research listed by Wake Forest includes identifying DNA targets, examining how membrane transport influences activity, and studying relationships between gene expression and drug sensitivity. The group also explores delivery formulations, including liposomal approaches. This is a preclinical research setting for people interested in medicinal and inorganic chemistry, where synthesizing a compound is paired with investigating how it reaches and affects cancer cells.
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