Nanomedicines and Translational Research Laboratory

University of Nebraska Medical Center

Mahato investigates how a therapy reaches the tissue where it is needed. His Nanomedicines and Translational Research Laboratory develops micelles, nanoparticles, polymers, and lipid-based systems for delivering drugs and nucleic acids, including siRNA and miRNA. Projects examine cancer, liver disease, and type 1 diabetes, alongside approaches to drug resistance and disease-related signaling. The group studies how delivery-system components affect drug deposition, tumor vessels, and surrounding tissue. This connects chemistry and formulation design with biological evaluation, aiming to improve targeted delivery and reduce unwanted effects on healthy tissue.